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Oral Testosterone Replacement Therapy: A New Option for Patients

a man taking a pill

The Advantages of OTRT for Busy Men 

Low testosterone levels in men are often treated with testosterone replacement therapy. Injectable testosterone has been the gold standard for decades, but did you know that there is a more convenient form of treatment available?

This article delves into oral testosterone replacement therapy, including its benefits and how it differs from traditional injectable therapy.

What is Oral Testosterone Replacement Therapy (OTRT)?

Oral testosterone replacement therapy is a less common type of TRT that is taken in pill form. The Food and Drug Administration has approved an oral formulation called Tlando (testosterone undecanoate) which is usually taken once or twice a day. 

Testosterone Undecanoate

Testosterone Undecanoate is the most popular oral testosterone replacement therapy medication produced by Marius Pharmaceuticals. One major benefit of oral testosterone undecanoate is the convenience of its oral administration. It is also preferred by patients who would rather not use injections or pellets. 

Other Benefits of OTRT

Other advantages of oral testosterone treatments include:

Restoration of Serum Testosterone Concentrations

One of the most significant benefits of OTRT is the restoration of serum testosterone levels in hypogonadal patients. OTRT aims to restore the testosterone levels to the normal range to alleviate the symptoms of hypogonadism.

Improvement of Muscle Mass and Cognitive Function

Multiple physiological functions in the human body, such as muscle mass and cognitive function, rely on adequate levels of endogenous testosterone. Supplementing low levels of endogenous testosterone can lead to an improvement in muscle mass and cognitive function for hypogonadal patients.

Decrease the Risk of Cardiovascular Diseases

A decrease in the levels of testosterone has been associated with an elevated risk of cardiovascular diseases, such as atherosclerosis, coronary artery disease, and hypertension. OTRT aims to restore normal testosterone levels, which may help reduce these risks.

Non-invasive Option

OTRT can offer additional benefits to certain patient populations who prefer non-invasive treatment options over other forms of testosterone replacement therapy

Potential Side Effects and Risks of Testosterone Therapy

Commonly reported side effects:

  • Acne or oily skin
  • Swelling or tenderness of breasts
  • Swelling of the ankles (fluid retention)
  • Decrease in the stream or frequency of urination
  • Laboratory abnormalities such as abnormal liver function tests
  • Headache
  • Gastrointestinal issues such as nausea and abdominal pain

Other potential side effects:

  • Red blood cell count increases
  • High blood pressure
  • An increased risk of heart attack and congestive heart failure with patients with existing heart problems

Who is a Good Candidate for Oral Testosterone Therapy?

Oral testosterone medications are a good option for many patients. It is especially appealing for patients who have busy schedules and cannot make regular trips to the doctor’s office for injections. Additionally, patients who are hesitant to undergo injectable therapy may find oral therapy to be a more appealing option.

Other Types of TRT

testosterone gel

Aside from oral medications, there are other types of TRT available in the market. These include:

Testosterone Pellets

Testosterone pellets are small, rice-sized pellets that contain testosterone and are inserted under the skin. They work by releasing testosterone into the body gradually. This allows for stable serum testosterone concentrations over an extended period, usually three to six months. 

Injectable Testosterone Formulations

Injectable testosterone formulations are a common treatment option for patients with hypogonadal conditions. This type of TRT is administered through intramuscular injections and provide long-term therapeutic benefits.

Testosterone Gels

Testosterone gels are a topical form of testosterone replacement therapy that is applied to the skin and is easily absorbed through it and into the bloodstream, leading to increased testosterone levels. Because of its convenience and ease of use, it has become a popular option among patients.

Testosterone Patches

Testosterone patches are another form of topical testosterone replacement therapy. These patches are applied to the skin and deliver a steady stream of testosterone over a 24-hour period. They are typically applied to the upper arm, thigh, or abdomen. Like testosterone gels, there is a risk of transferring the testosterone to others through skin-to-skin contact.

Consulting with a healthcare professional is crucial in determining the most appropriate type of TRT to minimize the risk of adverse effects. Contact Physician’s Rejuvenation Centers for your consultation today.

Is OTRT the Right Treatment Option for You?

Undergoing a comprehensive evaluation is essential before starting OTRT, as it may not be a suitable treatment option for everyone. This evaluation helps determine the safety and effectiveness of the treatment for an individual. This evaluation includes the following steps:

1. Assessing Symptoms of Hypogonadism

It is essential to assess your symptoms and medical history to identify if you are a good candidate for OTRT. 


  • Tiredness
  • Low energy levels
  • General Malaise
  • Decreased libido
  • Erectile dysfunction
  • Fatigue
  • Decreased muscle mass

During the assessment process, medical professionals will also check for other symptoms including osteoporosis, lipid disorders, infertility, and cognitive function.

2. Normal Range and Tests for Serum Testosterone Concentrations

The normal range for serum testosterone concentrations varies depending on factors including age and sex. In adult men, the normal range is typically between 300 and 1000 ng/dL

To measure serum testosterone concentrations, doctors can perform several tests including the total testosterone test and the free testosterone test.

  • Total testosterone test measures the total amount of testosterone in the bloodstream, including both bound and unbound testosterone. 
  • Free testosterone test measures the amount of unbound testosterone that is available to the body for various functions.

Factors Affecting Serum Testosterone Concentrations

3. Assessing Lean Body Mass and Bone Mineral Density

Our overall health and quality of life are influenced by factors such as lean body mass and bone mineral density. Lean body mass is often used as a measure of physical fitness and functional capacity, while bone density serves as an indicator of the mineral content present in bones.

4. Liver Function Tests and Blood Cell Counts

Liver function tests should always be ordered prior to starting OTRT due to the potential for liver toxicity. OTRT is metabolized by the liver, which can cause elevated liver enzyme levels and liver damage in some patients. Therefore, determining a patient’s baseline liver function is necessary before initiating OTRT to monitor for any changes or adverse effects on the liver.

5. Checking Other Medical Conditions and Blood Pressure Readings

OTRT might not be a suitable treatment option for individuals with specific medical conditions, such as congestive heart failure, as it could exacerbate heart failure symptoms and increase the possibility of cardiovascular events, including deep vein thrombosis or heart attack.

6. Determining Adverse Effects of OTRT

It is important to consider the potential adverse effects associated with OTRT. Here are some of the possible adverse effects and precautions that should be taken to minimize risks:

Side EffectsDescription
Cardiovascular EffectsStudies suggest a potential link between testosterone therapy and increased risk of cardiovascular disease, especially in patients with a history of cardiovascular disease. Close monitoring is essential for these patients.
Water RetentionOTRT may cause water retention, especially in patients prone to this condition. Patients who experience swelling or bloating should contact their healthcare provider immediately.
GynecomastiaTestosterone therapy may cause an increase in breast tissue in men, known as gynecomastia. This side effect can be addressed by adjusting the dosage or form of therapy and requires close monitoring.
Elevated Red Blood Cell CountOTRT may increase the number of red blood cells in some patients, leading to a condition called polycythemia that can heighten the risk of blood clots. Close monitoring of a patient’s red blood cell counts is essential to prevent this potential side effect.
Patient ComplianceNoncompliance with OTRT regimens can increase the risk of adverse reactions. It is essential to ensure patient adherence to the prescribed medication dosage to reduce the risk of harmful side effects.

Contact Physician’s Rejuvenation Centers for the Best Testosterone Replacement Therapy Options

If you have any questions regarding the best testosterone replacement therapies and other rejuvenating treatments, don’t hesitate to contact Physician’s Rejuvenation Centers. We have a team of specialists committed to delivering safe and efficient treatments customized to your individual needs.

Oral testosterone treatments may lead to potential side effects that require constant monitoring. Thus, seeking advice from our knowledgeable physicians can help guarantee the effectiveness of your treatment plan and ensure your safety.

At Physician’s Rejuvenation Centers, we prioritize patient safety and take the time to understand your individual needs and goals. Contact us today to schedule your consultation and take the first step towards a healthier, more energized you!