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Testosterone Replacement Therapy Options

testosterone replacement therapy

Understanding Hypogonadism and Its Effects on Testosterone Levels and Your Health

Testosterone is a hormone that plays a crucial role in the male body, affecting everything from sexual desire to muscle mass and bone density. Unfortunately, as men age, their testosterone levels may decline, leading to symptoms such as fatigue, decreased sex drive, and mood swings. If you’re experiencing these symptoms, you may be wondering about testosterone replacement therapy options.

In this article, we’ll explore the different types of testosterone replacement therapy available, their pros and cons, and how they work. So, let’s dive in and find out how testosterone replacement therapy can help you feel like your old self again!

Testosterone Replacement Therapy

Testosterone replacement therapy (TRT), also known as androgen replacement therapy (ART), is a medical treatment prescribed to individuals with low levels of testosterone. The therapy involves increasing the amount of testosterone in the body either through injections, topical gels or patches, pellets, or oral medications.

Beneficial Effects of Testosterone on the Body

Testosterone on Bone

Testosterone plays a crucial role in maintaining bone health, helping to increase bone mineral density and reduce the risk of fractures.

Testosterone on Libido

Testosterone is known for its impact on sexual function and desire, with increased testosterone levels often leading to improved libido and erectile function in men.

Testosterone on Muscle

Testosterone helps to increase muscle mass and strength, making it an important hormone for athletes and fitness enthusiasts.

Testosterone on Mood

Testosterone has been shown to have a positive impact on mood and cognitive function, with some studies suggesting that low testosterone levels may be associated with an increased risk of depression.

Testosterone on Energy

Testosterone can help to increase energy levels and improve overall physical performance, making it an important hormone for individuals who lead an active lifestyle.

Testosterone on Metabolism

Testosterone has been shown to improve insulin sensitivity and glucose metabolism, which may help to reduce the risk of type 2 diabetes and other metabolic disorders.

Testosterone Level and Effects of Hypogonadism

Testosterone is an essential male hormone responsible for a variety of physical and mental functions. However, testosterone levels can decline with aging, leading to a condition known as hypogonadism. 


Low testosterone levels are medically known as hypogonadism. This occurs when insufficient amounts of sex hormone androgens in males are produced in the testicles of the scrotum.

If you are suffering from type 2 diabetes, obesity, renal failure, HIV, hypertension, chronic obstructive pulmonary disease (COPD), and are taking glucocorticoid (steroids), opioid, or antipsychotic medication therapy, you are at risk of developing this condition.

Hypogonadism can be classified into primary and secondary hypogonadism.

  1. Primary hypogonadism (hypergonadotropic hypogonadism) occurs when there is a problem with the testicles that doesn’t allow them to make normal levels of testosterone.
  2. Secondary hypogonadism (hypogonadotropic hypogonadism) occurs when there is a problem in the hypothalamus or the pituitary gland that signals the testicles to produce testosterone.


There are several causes why people develop either primary or secondary hypogonadism:

Primary HypogonadismSecondary Hypogonadism
Klinefelter syndromePituitary disorders
Leydig cell hypoplasiaInflammatory disease
Noonan syndromeOpiates
Myotonic dystrophyNormal aging
Mumps infection
Increased iron load in the blood
Cancer treatment

Symptoms and Health Complications Associated with Hypogonadism

Hypogonadism can have a range of physical and emotional symptoms in men. The most common symptoms of hypogonadism include:

  • Decreased energy levels
  • Decreased sexual function and desire for sex
  • Increased body fat
  • Decreased muscle mass and strength
  • Decreased bone mineral density
  • Hot flashes
  • Depression
  • Decreased motivation
  • Feelings of fatigue

But the impact of low testosterone on overall health goes beyond these symptoms. Men with low testosterone are at an increased risk of developing the following conditions:

Diagnosis and Treatment of Low Testosterone Levels

blood test

Diagnosing Hypogonadism

Hypogonadism is diagnosed through a variety of symptoms, including decreased energy levels, sexual dysfunction, decreased muscle mass, and bone density loss. To confirm a diagnosis, healthcare providers may order a blood test to measure testosterone concentration in the bloodstream.

Treatment of Hypogonadism

The most common treatment option for hypogonadism is testosterone replacement therapy (TRT).

TRT involves supplementing the body with testosterone using various methods. Injections of testosterone esters are a common method of administration, as are gels, patches, and pellets. There are also various forms of oral testosterone available, including testosterone undecenoate.

Forms of Testosterone Replacement Therapies

There are several options available for testosterone administration, each with its own pros and cons.


Injections of testosterone are a popular form of TRT as they provide a quick and significant boost in testosterone levels. However, the duration of effect is typically short-lived, and injections can be painful to administer.


Transdermal testosterone gel is another option for TRT. The gel is applied to the skin each day, and testosterone is gradually absorbed into the bloodstream. This form of TRT has a more consistent effect than injections, but it can be messy and may cause skin irritation.


Testosterone patches are a form of transdermal TRT that can be easy to use. Like the gel, the patch delivers testosterone to the bloodstream over time. However, the patch can be expensive and may cause skin irritation.

Oral Medications

Medications such as oral testosterone undecenoate are approved by the Food and Drug Administration. These are easy to take, but their absorption rate can be unpredictable. Additionally, these medications may place additional stress on the liver.

Nonscrotal Permeation-enhanced Testosterone Transdermal System

This is an innovative alternative to the traditional transdermal gel and patch. This system delivers testosterone through the skin using a unique, noninvasive device, resulting in consistent and predictable levels. One downside is that this method is still relatively new, and its long-term effects are still being studied.

Choosing a Testosterone Replacement Therapy Option

The choice of TRT depends on the severity of hypogonadism, personal preferences, overall health, and medical history. Injections may be ideal for men who want a quick and significant boost in testosterone levels. In contrast, transdermal options may better suit men who prefer a slower, more consistent delivery of testosterone.

It is best to consult a healthcare provider to ensure your safety and the effectiveness of testosterone therapy. Book a consultation with Physician’s Rejuvenation Centers today and explore our wide range of rejuvenation treatments that can suit your needs!

Potential Side Effects of Testosterone Replacement

While TRT can be an effective treatment for various conditions related to low testosterone levels, it is important to be aware of the potential side effects and risks associated with this therapy. It is crucial to have a thorough discussion with your healthcare provider before starting TRT to fully understand the risks and benefits of the treatment. Here are some potential side effects and risks associated with TRT that you should be aware of:

Common Side Effects

  1. Acne: An increase in testosterone levels can cause an increase in oil production, which may lead to acne.
  2. Breast enlargement: Testosterone can sometimes be converted into estrogen in the body, leading to breast tissue growth in men.
  3. Sleep apnea: TRT can worsen sleep apnea symptoms by causing further relaxation of the muscles in the throat.
  4. Decreased sperm production: TRT can lead to a decrease in sperm production, which could result in infertility.

Long-term Testosterone Replacement Effects

One of the most significant risks is an increased risk of prostate cancer. While research on the topic is mixed, some studies have found that men on TRT may have a higher risk of developing prostate cancer or having existing prostate cancer worsen.

Another potential risk associated with TRT is cardiovascular disease. Some studies have shown that men on TRT may have an increased risk of heart attack, stroke, and other cardiovascular issues. This risk may be especially significant in older men or those with preexisting cardiovascular conditions.

TRT may also affect insulin sensitivity, which can lead to insulin resistance and an increased risk of type 2 diabetes.

Get Safe and Effective Testosterone Replacement Therapy with Physician’s Rejuvenation Centers

Testosterone replacement therapy can be a highly effective treatment for low testosterone levels. At Physician’s Rejuvenation Centers, our team of experts has years of experience in providing safe and effective testosterone replacement therapy to individuals of all ages.

We understand that choosing a TRT option can be overwhelming, but our team is here to help guide you through the process. We take into consideration your personal preferences, medical history, and overall health when recommending a TRT option that will work best for you.

Contact Physician’s Rejuvenation Centers today to schedule a consultation and learn more about our safe and effective testosterone replacement therapy options.